Center for Human Genetics and Laboratory Diagnostics, Dr. Klein, Dr. Rost and Colleagues

Hepatitis D Virus (HDV)

Dr. med. Hartmut Campe, Dr. med. Hanns-Georg Klein

Scientific Background

Hepatitis D Virus (HDV) infection occurs only as a superinfection or coinfection with a hepatitis B virus infection. It is usually acquired through blood contact, and less often through sexual contact.

As with HBV monoinfection, acute and chronic disease is possible following HDV infection. Superinfection in a patient with chronic HBV infection usually leads to chronic HDV infection.

Sequelae such as cirrhosis (loss of function of the liver due to connective tissue replacement of destroyed cells) and hepatocellular carcinoma occur quicker than with a HBV monoinfection.

HDV infection is treated with the HBV infection.

HDV infection is diagnosed through serology.